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In addition to inducing clonogenic death, the exposure of metformin reduced the size of the colonies formed and decreased the cell density in the colonies data not shown suggesting that metformin not only kills cancer cells but also suppresses the proliferation of surviving cancer cells, which is in agreement with the reports of other investigators 15, 16 .

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should secondary failure occur with combined amaryl m metformin hydrochloride hydrochloride tablets sulfonylurea therapy, it may be necessary to consider therapeutic alternatives including initiation of insulin therapy.

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